2022 Measure # 176 Tuberculosis Screening Prior to First Course Biologic Therapy

Measure Type High Priority Measure? Collection Type(s)
Process no MIPS CQM

Measure Description

If a patient has been newly prescribed a biologic disease-modifying anti-rheumatic drug (DMARD) therapy, then the medical record should indicate TB testing in the preceding 12-month period.

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This measure is to be submitted a minimum of once per performance period for patients who are being considered or prescribed a first course of biologic disease-modifying anti-rheumatic drug therapy seen during the performance period. This measure may be submitted by Merit-based Incentive Payment System (MIPS) eligible clinicians who perform the quality actions described in the measure based on the services provided and the measure-specific denominator coding.

NOTE: Patient encounters for this measure conducted via telehealth (e.g., encounters coded with GQ, GT, 95, or POS 02 modifiers) are allowable.

Measure Submission Type:

Measure data may be submitted by individual MIPS eligible clinicians, groups, or third party intermediaries. The listed denominator criteria are used to identify the intended patient population. The numerator options included in this specification are used to submit the quality actions as allowed by the measure. The quality-data codes listed do not need to be submitted by MIPS eligible clinicians, groups, or third party intermediaries that utilize this modality for submissions; however, these codes may be submitted for those third party intermediaries that utilize Medicare Part B claims data. For more information regarding Application Programming Interface (API), please refer to the Quality Payment Program (QPP) website.


All patients aged 18 years and older who are receiving a first course of therapy using a biologic DMARD

Denominator Instructions:
Patients are considered to be receiving a first course of therapy using a biologic DMARD only if they have been prescribed DMARD biologic therapy during the measurement period and also have not been prescribed DMARD biologic therapy in the 15 months preceding the encounter where DMARD biologic therapy was newly started. Biologic DMARD therapy includes:
– Abatacept (Orencia)
– Adalimumab (HUMIRA)
– Anakinra (Kineret)
– Baricitinib (Olumiant)
– Canakinumab (ILARIS)
– Certolizumab pegol and lyophilized certolizumab pegol (CIMZIA)
– Etanercept (Enbrel)
– Golimumab (Simponi)
– Guselkumab (Tremfya)
– Infliximab (REMICADE)
– Infliximab-abda (Renflexis)
– Infliximab-axxq (Avsola)
– Infliximab-dyyb (Inflectra)
– Ixekizumab (Taltz)
– Sarilumab (KEVZARA)
– Secukinumab (Cosentyx)
– Tocilizumab (ACTEMRA)
– Tofacitinib (XELJANZ)
– Upadacitinib (RINVOQ)
– Ustekinumab (STELARA)

The list of biologic DMARD therapies is subject to change as new therapies are approved by the FDA.

To be included in the denominator, patient must have an encounter and a prescription for DMARD biologic therapy in the measurement period (1/1/2022-12/31/2022) WITHOUT a prior prescription for DMARD biologic therapy within the 15 months prior to the DMARD prescribed during the measurement period.

DENOMINATOR NOTE: *Signifies that this HCPCS code is a non-covered service under the Medicare Part B Physician Fee Schedule (PFS). These non-covered services should be counted in the denominator population for the MIPS CQMs.

Denominator Criteria (Eligible Cases):
Patients aged ≥ 18 years on date of encounter


Patient encounter during the performance period (CPT or HCPCS): 99202, 99203, 99204, 99205, 99212, 99213, 99214, 99215, 99341, 99342, 99343, 99344, 99345, 99347, 99348, 99349, 99350, 99424, 99426, G0402, G0468*


Patient receiving first-time biologic disease modifying anti-rheumatic drug therapy: G2182


Patients for whom any record of TB testing is documented or performed (PPD, IFN-gamma release assays, or other appropriate method) in the medical record in the 12 months preceding the biologic prescription.

Numerator Options:

Performance Met:

TB screening performed and results interpreted within twelve months prior to initiation of first-time biologic disease modifying anti-rheumatic drug therapy (M1003)


Denominator Exception:

Documentation of medical reason for not screening for TB or interpreting results (i.e., patient positive for TB and documentation of past treatment; patient who hasrecently completed a course of anti-TB therapy) (M1004)


Performance Not Met:

TB screening not performed or results not interpreted, reason not given (M1005)


CMS-Dermatology-2022, CMS-Rheumatology-2022, NonTelehealth-2022, Quality-2022, Rheumatology-2022